DCE-MRI参数联合IFIT1基因对腰椎间盘突出患者椎间盘退变程度的评估价值

探讨DCE-MRI参数及IFIT1基因对腰椎间盘突出症(LDH)患者椎间盘退变(IDD)程度的评估价值。随机选取确诊的66例LDH患者作为研究对象,根据改良Pfirrmann分级法将患者分为2组:轻中度IDD(Ⅰ~Ⅲ级)组(46例)和重度IDD(Ⅳ~Ⅴ级)组20例。通过DCE-MRI检查考察患者的K-trans值,采用日本骨科学会评分(JOA)评估腰椎功能,采用视觉模拟评分法(VAS)评估腰部疼痛,采用RT-PCR检测外周血单个核细胞(PBMC)中IFIT1的mRNA表达。轻中度IDD组的K-trans值显著低于重度IDD组。轻中度IDD组患者PBMC中的IFIT1 mRNA相对表达量显著低于重度IDD组。K-trans值与PBMC中的IFIT1 mRNA水平和VAS评分正相关,与JOA评分负相关(P<0.05)。PBMC中的IFIT1 mRNA水平与VAS评分正相关,与JOA评分负相关(P<0.05)。K-trans值和PBMC中的IFIT1 mRNA水平联合诊断重度IDD的AUC值、敏感性和特异性分别为0.991、91.3%和100.0%,AUC值和特异性均高于单独诊断。DCE-MRI检查中的K-trans值联合PBMC中的IFIT1 mRNA水平可用于LDH患者IDD程度的诊断。     

MRI参数对腰椎间盘突出症患者椎间盘退变程度的评估价值及与JOA、VAS评分相关性

选择腰椎间盘突出症(LDH)患者60例,分为轻度退变组、中度退变组、重度退变组。患者均行MRI检查,比较3组的MRI参数,包括髓核(NP)区、纤维环(AF)区T2值。检测比较发现,3组LDH患者NP区、AF区T2值间存在明显差异,且与腰椎功能评分(JOA)呈正相关,与腰部疼痛评分(VAS)呈负相关(P<0.05)。NP区、AF区T2值联合鉴别轻中度、中重度椎间盘退变程度的AUC大于各指标单一鉴别,具有较高评估效能。因此,MRI参数评估LDH患者椎间盘退变程度方面具有良好价值,可为临床明确患者病情提供重要参考。     

Two Zn(II)‐based meta‐organic frameworks: Selective detection of antibiotics and treatment activity on age‐related macular degeneration by reducing inflammasome activation

Via utilizing the mixed‐ligand method, two novel Zn(II)‐containing meta‐organic frameworks with the chemical formula of {[Zn(L)(5‐HIP)]·H₂O}_n ( 1 ) and [Zn(L)(2,6‐NDC)]_n ( 2 ) were prepared under the solvothermal conditions by applying aromatic dicarboxylic acids ligands (5‐H₂HIP = 5‐hydroxyisophthalic acid; 2,6‐H₂NDC = 2,6‐naphthalenedicarboxylic acid) and 1,4‐bis(benzimidazol‐1‐yl)‐2‐butylene (L). Due to its good water stability as well as the strong luminescent emission around room temperature, complex 2 has the high selectivity and sensibility of fluorescence detection to the ceftriaxone sodium (a kind of antibiotic) with the detection limit up to ppm lever. The treatment activity of the compounds on age‐related macular degeneration was assessed and the specific mechanism was investigated. First of all, the inflammasome activation in the endothelial cells of retina was evaluated with western blot. In addition to this, the down‐stream production of the inflammasome activation was also measured with ELISA detection kit.     

Slipping zone location in squeeze flow

In squeeze flow rheometry, the main problem is the boundary condition between the squeezed material and the plates. Therefore, the crucial assumption is to know the location and the shape of the sample part where wall slip may or may not occur. This question is investigated from experimental results. For this, squeeze flow experiments are carried out to visualize the flow pattern at the walls. Influence of boundary conditions is particularly studied using different plate surface condition. As a result, with wall slipping conditions, we propose a flow modelling divided into two zones: a circular central zone of the sample sticks on the plates and, beyond that zone, the sample slips at the plates with friction.     

肝豆状核变性患者的肾脏病变特点及长期使用青霉胺的影响研究

目的 探讨肝豆状核变性患者肾脏病变的特点及长期使用青霉胺治疗对其产生的可能影响。方法 选取70 例临床 确诊为肝豆状核变性患者作为观察组,根据临床表型和使用青霉胺时间分为肝脏型组、肝脑混合型组、脑型组及使用青霉胺＜5年组、5～10 年组、＞10 年组,检测并比较各组患者尿总蛋白（TG）、低分子量蛋白（LMW）、高分子量蛋白（HMW）、β2微球蛋白（β2-MG）、β－N-乙酰氨基葡萄糖苷酶（NAG）、白蛋白（ALG）及血肌酐（Scr）等肾脏病变相关指标;另选择无血缘关系且血铜蓝蛋白及铜氧化酶等铜代谢检查均正常的健康志愿者70 例作为对照组,检测上述指标并与观察组对照。结果 观察组的肾脏病变相关指标显著高于对照组;不同临床表型的患者各项指标间无统计学差异;随着服用青霉胺时间的延长,患者尿液中β2-MG、LMW百分比、NAG、TG水平逐渐降低,HMW 百分比、ALG水平逐渐升高,TG 呈现逐渐降低的趋势,Scr 保持不变。结论 肝豆状核变性患者肾小球和肾小管的功能均有明显的损伤;肾脏病变在不同临床表型之间无统计学差异,长期使用青霉胺治疗对肾小球的功能有一定的损伤。     

Controlling phonon squeezing and correlation via one- and two-phonon interference

When ultrafast laser pulse strikes the crystal with a van Hove singularity in the phonon density of states, it can create a pair of anti-correlated in wave-vector phonons. As a result, the atomic fluctuations in either position or momentum become squeezed in such a way that their size might fall below the vacuum level. The ultrafast pulses can also generate a biphonon state in which the constituent phonons are correlated and/or entangled. Here we show that via the interplay between one- and two-phonon interference the bound and squeezed two-phonon state in (110) oriented ZnTe single crystal can be manipulated.     

Uncertainty relations for a q-deformed coherent spin state

A Coherent Spin State (CSS) is defined as an eigenstate of the spin component in the direction specified by angles (θ₀,?₀). This state satisfies minimum uncertainty relation, with uncertainties equally distributed on any two orthogonal components normal to the direction of the total spin vector 〈S〉. Starting from this concept, we apply the notion of CSS to quantum groups and discuss the properties of q-deformed CSS and the associated uncertainty relations. We show that these states behave as Intelligent Spin States (ISS) on two orthogonal components normal to the direction of the mean value of the spin operator.